RESEARCHERS at the Shanghai Institutes for Biological Sciences and Tongji University have gained new insight into how adult cells can be induced to act like embryonic stem cells (ESC) with the ability to form any type of tissue known as "pluripotency."
In collaboration with Agilent Technologies, the study focused on finding less ethically challenging alternatives to stem cell research.
A main focus of the research was investigating the inducement of pluripotency and its role in the body.
The researchers observed a developmental signaling network of 16 signaling pathways, including nine that had not previously been assigned roles in maintaining or inducing pluripotency.
The study used Agilent chromatin immunoprecipitation-on-chip (ChIP-on-chip) and gene expression microarrays to study molecules known as "Yamanaka factors" and their roles in inducing pluripotency in mouse cells.
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