Sigma-Aldrich has launched its SAGEspeed(TM) program for faster production of genetically modified rats and mice. The program is said to enable researchers to have knockout rats and mice produced in as little as four to five months.
SAGEspeed uses Sigma-Aldrich’s proprietary novel CompoZr™ Zinc Finger Nuclease (ZFN) gene editing technology. The company claims that the SAGEspeed reduces the cycle time taken to create knockout mouse models using conventional embryo stem (ES) cell-based technologies by around two-thirds.
Additionally, SAGEspeed can also create targeted knockout rats. The knockout rodent models are created using CompoZr to deactivate or 'knockout' specific genes associated with certain human disease conditions.The SAGEspeed program is available through Sigma Advanced Genetic Engineering (SAGE™) Labs (www.sigma.com/sagelabs).
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